Sesame Summit 2026 – application open

Healthspan vs Lifespan

Let’s delve into the highlights of the event and explore the pioneering individuals who left an indelible mark on the attendees.

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  1. Bryan Johnson: Also known as the most measured man in human history, Bryan is an advocate for being the next evolution of human and building one’s autonomous self through a way of life for which he has a “Blueprint”. Using this methodology, Bryan’s successes include:
    + Slowed pace of aging by equivalent 31 years
    + Now aging slower than the average 10 yr old
    + Body inflammation is 66% below the average 10 year old
    + Ideal muscle & fat (MRI)
    + 50+ optimal clinical outcome biomarkers
    + 100+ markers < chronological age
    + Several fitness tests = 18yr old
    + Body runs 3F° cooler
    + 12 year age reversal in 500 day average HRV
    + 31 year age reversal in grey hair age (80% reduction in grey hair)
    + 2 month streak of 100% sleep performance (data via Whoop)
  2. Elizabeth Angel (yours truly): Led a panel on Digital Wellness. The panel delved into the crucial topic of understanding our digital landscape and harnessing its potential while being mindful of the challenges it presents. My goal was to shed light on the importance of digital literacy and responsible engagement with emerging technologies. My expertise in navigating the complexities of the digital world and fostering a healthy digital ecosystem seemed to resonate deeply with the audience. The panel sparked meaningful conversations and empowered attendees and especially parents to approach the digital realm with awareness and confidence.
  3. Nicole Gibson: Advancing Mental Health with InTruth.io, Nicole Gibson is a mental health advocate and the founder of a revolutionary platform that provides accessible and personalized mental health support. The platform employs AI-powered technology to offer users personalized coaching and support that is tailored to their unique needs. InTruth.io is designed to provide mental health support in real-time, using a conversational interface that fosters a safe and non-judgmental environment.
  4. Shawn Sherman: With an Exercise and Sport Science degree from Penn State University and a private practice in Western Springs, Illinois, Shawn’s expertise in movement over the past 25 years with the revolutionary approach,  SQUARE 1 System™, has yielded remarkable results for his clients. By challenging conventional thinking and drawing on his extensive experience, he has developed a methodology that consistently delivers exceptional outcomes. Shawn has consulted with a vast array of elite athletes and sports organizations. His expertise has been sought by renowned teams such as the Chicago Cubs, Chicago Bulls, Chicago Blackhawks, and the United States Olympic Team, to name just a few. Tom Ford, the Director of Sports Medicine at Oakland University, commended Shawn’s contribution to an athlete’s performance: “We did not even know if Derick (Nelson) was going to be able to play, and then Shawn worked on him, and all of a sudden, he played the game of his life!

Healthspan vs. Lifespan: Unveiling the Difference

Throughout the Healthspan Summit, a recurring theme that intrigued both experts and attendees alike was the concept of healthspan versus lifespan. While the term “lifespan” refers to the total duration of a person’s life, “healthspan” emphasizes the quality of life and well-being during that time.

Understanding the distinction between these two concepts is crucial in today’s age of scientific advancements. Healthspan aims to enhance not only the length of our lives but also the vitality and wellness we experience throughout. It entails efforts to prevent age-related diseases, promote healthy lifestyles, and optimize our overall well-being.

A Promising Ecosystem: Just the Beginning

This first Healthspan Summit was not merely an isolated gathering but rather the beginning of an exciting ecosystem. It brought together brilliant minds, ideas, and initiatives that will shape the future of technology, health, and beyond. The event served as a catalyst for fostering collaborations, sparking innovation, and creating a positive impact on society.

During this dynamic event in LA, luminaries like Bryan Johnson and Elizabeth Angel shared their transformative insights, captivating the audience with their groundbreaking work. Discussions around healthspan versus lifespan and digital awareness opened up new avenues for exploration and understanding. This event is just the first chapter of an ecosystem brimming with possibilities. As we eagerly look ahead, we anticipate even greater achievements and groundbreaking discoveries in the near future. Stay tuned for more exciting developments and let your curiosity fuel your journey of discovery in this ever-evolving landscape of innovation.

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Fundraising 5 hours ago

London-based AI laboratory Ineffable Intelligence has emerged from stealth with a $1.1 billion seed round at a $5.1 billion post-money valuation, the company confirmed on 27 April 2026. The financing is the largest seed round ever raised by a European company and one of the largest first-money-in rounds in the global history of artificial intelligence. The round was co-led by Sequoia Capital and Lightspeed Venture Partners. Participating investors included Nvidia, DST Global, Index Ventures, Google, and the UK Sovereign AI Fund, the British government’s recently established vehicle for backing strategic AI capacity on home soil. A bet on a different path to general intelligence Ineffable Intelligence was founded in 2025 by David Silver, the former Vice President of Reinforcement Learning at Google DeepMind and the principal architect of AlphaGo, AlphaZero and AlphaStar. He is joined by three further DeepMind alumni: Wojciech Czarnecki, Lasse Espeholt and Junhyuk Oh. All four have spent the past decade at the frontier of reinforcement learning research, the discipline behind some of the most consequential demonstrations of machine learning over the past ten years. The company describes its objective as building a “superlearner” — an AI system capable of acquiring knowledge directly from its own experience rather than from human-generated text or imagery. “Our mission is to make first contact with superintelligence,” Silver said in a statement accompanying the launch. “We are creating a superlearner that discovers all knowledge from its own experience, from elementary motor skills through to profound intellectual breakthroughs.” The framing is a deliberate departure from the dominant industry trajectory. Most leading AI laboratories, including OpenAI, Anthropic and Google DeepMind itself, have built large language models trained primarily on the corpus of the internet, then refined that training with human feedback. Ineffable’s wager is that the marginal returns on scaling text-based pretraining are diminishing and that the next leap in capability will come from agents that learn endlessly from the consequences of their own actions, in much the same way AlphaZero learnt the game of Go without studying any human matches. Why $1.1 billion at seed The size of the round is unusual even by the inflated standards of the 2026 AI capital cycle. Two factors appear to explain it. First, frontier reinforcement learning at the scale Ineffable describes is computationally extraordinarily expensive: the company will need to operate vast simulation environments and train very large models against them, an undertaking that consumes capital at a rate closer to physical R&D than to traditional software. Second, the round signals a strategic move by Europe’s investor and policy ecosystems to retain the most ambitious AI researchers on the continent. The presence of the UK Sovereign AI Fund alongside Sequoia, Lightspeed and Nvidia is the clearest expression of that intent. The British government has publicly framed the investment as a bet on breakthrough AI that “can discover new knowledge”, positioning the country as a willing co-investor in domestic frontier laboratories. For Ineffable, the implication is access not only to capital but to compute, regulatory engagement and the still-resilient academic talent base around UCL, Oxford, Cambridge and Imperial. Founder pledge of historic scale Alongside the funding announcement, Silver disclosed that he is committing 100 per cent of any personal proceeds from his Ineffable equity to charity via the Founders Pledge network — described by the organisation as the largest pledge in its history. At the round’s $5.1 billion valuation, that commitment could ultimately exceed several billion dollars if the company succeeds. It is a meaningful gesture in a sector where the reputational stakes around concentrated AI wealth are escalating, and one likely to be referenced in subsequent founder-led commitments. Implications for the European AI landscape Ineffable’s emergence reshapes the European AI map in three concrete ways. It establishes London as the home of the continent’s largest-ever seed-stage company, complicating Paris’s recent narrative of frontier-AI primacy after Mistral’s earlier rounds. It validates a thesis — that reinforcement learning, not transformer scaling, is the next frontier — that has lately been losing capital share to language-model incumbents. And it confirms that the UK government is now willing to act as a balance-sheet co-investor in domestic AI laboratories, a posture much closer to the French model than to the predominantly grant-based regimes elsewhere in Europe. The execution risk is non-trivial. Reinforcement learning at frontier scale has historically required years of careful environment design before producing competitive systems, and Ineffable’s “first contact” framing sets a high bar against which it will be judged. But for now, with a billion dollars on the balance sheet, four of the discipline’s most accomplished researchers in the founding team and a sovereign co-investor at its back, Ineffable Intelligence is the most heavily resourced new entrant in the European AI cycle. Sesamers covers European fundraising rounds across deeptech, fintech and AI. Source: tech.eu.

Fundraising 5 days ago

Belfast's Cloudsmith has raised $72M Series C led by TCV, with Insight Partners participating, to expand its artifact management platform and secure the AI-era software supply chain.

Fundraising 5 days ago

Berlin’s VREY has raised €3.3M seed led by Rubio Impact Ventures to roll out rooftop solar software for Germany’s multi-family buildings.

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